+25 Peptide Bond Synthesis 2023. Catalysis is key to circumvent current bottlenecks. When they bind to the rrna of the large subunit, it prevents the formation of the peptide bond and promotes the early expulsion of the trna in the p site.

To illustrate the impact of. Web the macrolide antibiotics act on the 50s large ribosomal subunit. Web here, the authors report a general synthetic strategy for fast formation of two and three disulfide bonds in peptides and proteins, and apply it to prepare several therapeutically important peptides.